Persistence of Haemoglobin

Interaction of Beta-thalassaemia and Hereditary Persistence of Foetal Haemoglobin.

Hereditary persistence of foetal haemoglobin (HPFH) is a term used to describe an inherited high level of Hb-F which is present throughout life and is not associated with anaemia. In that respect and by showing interaction with the S and C variants of adult haemoglobin, it resembles ,3-thalassaemia, and at one time it was described as 'non-microcythaemic thalassaemia'. There are, however, 3 fun...

Hereditary persistence of foetal haemoglobin in members of two Chinese families in Taiwan.

Assessment of fetal-maternal haemorrhage in mothers with hereditary persistence of fetal haemoglobin.

Kleihauer examination of peripheral blood cannot be used reliably to detect transplacental fetal-maternal haemorrhage in mothers with hereditary persistence of fetal haemoglobin (HPFH). In Rh(D) negative pregnancies diagnostic confusion with a large fetal-maternal haemorrhage could result in the administration of inappropriately excessive amounts of anti-D immunoglobulin, and the inability to d...

A case of multople chromosomal rearrangements with persistence of foetal haemoglobin.

Retinal changes in sickle cell/hereditary persistence of fetal haemoglobin syndrome.

We describe for the first time retinal changes in sickle cell/hereditary persistence of fetal haemoglobin syndrome, which is a rare and benign disorder. The changes are qualitatively similar to retinal disease seen with sickle haemoglobin and sickle C haemoglobin, but are mild.